Microwave-Assisted Synthesis of Imidazo[4,5-f][1,10]phenanthroline Derivatives as Apoptosis Inducers in Chemotherapy by Stabilizing Bcl-2 G-quadruplex DNA

Herein, a series of imidazo[4,5-f][1,10] phenanthroline derivatives RPIP (PIP = imidazo [4,5-f][1,10] phenanthroline, R = NO(2), 1; CF(3), 2; Cl, 3; OH, 4) have been synthesized in yields of 82.3–94.7% at 100 °C under the irradiation of microwave. MTT assay has been utilized to evaluate the inhibito...

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Detalles Bibliográficos
Autores principales: Li, Li, Cao, Jie-Qiong, Liu, Hui-Min, Wu, Qiong, Pan, Qiu-Hui, Zeng, Zhi-Ping, Lan, Yu-Tao, Li, Yu-Mei, Mei, Wen-Jie, Wang, Xi-Cheng, Zheng, Wen-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154642/
https://www.ncbi.nlm.nih.gov/pubmed/28531122
http://dx.doi.org/10.3390/molecules22050829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154642/
https://www.ncbi.nlm.nih.gov/pubmed/28531122
http://dx.doi.org/10.3390/molecules22050829

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