Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods

The pentacyclic triterpene oleanolic acid (OA, 1) with known farnesoid X receptor (FXR) modulatory activity was modified at its C-3 position to find new FXR-interacting agents. A diverse substitution library of OA derivatives was constructed in silico through a 2D fingerprint similarity cluster stra...

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Detalles Bibliográficos
Autores principales: Wang, Shao-Rong, Xu, Tingting, Deng, Kai, Wong, Chi-Wai, Liu, Jinsong, Fang, Wei-Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154651/
https://www.ncbi.nlm.nih.gov/pubmed/28445411
http://dx.doi.org/10.3390/molecules22050690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154651/
https://www.ncbi.nlm.nih.gov/pubmed/28445411
http://dx.doi.org/10.3390/molecules22050690

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