Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors()

The phosphoinositide 3-kinase–related kinase ATR is a central regulator of the DNA damage response. Its chemical inhibition eliminates subsets of cancer cells in various tumor types. This effect is caused at least partly by the synthetically lethal relationship between ATR and certain DNA repair gen...

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Detalles Bibliográficos
Autores principales: Job, Albert, Schmitt, Lisa-Maria, von Wenserski, Lisa, Lankat-Buttgereit, Brigitte, Gress, Thomas M., Buchholz, Malte, Gallmeier, Eike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154763/
https://www.ncbi.nlm.nih.gov/pubmed/30257222
http://dx.doi.org/10.1016/j.neo.2018.08.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154763/
https://www.ncbi.nlm.nih.gov/pubmed/30257222
http://dx.doi.org/10.1016/j.neo.2018.08.009

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