CDK4, a new metabolic sensor that antagonizes AMPK

Cyclin-dependent kinase 4 (CDK4) is a positive regulator of cell cycle progression, however, there is growing evidence demonstrating that its function exceeds the control of cell division. Here we show that CDK4 is an important regulator of cellular substrate utilization through direct inhibition of...

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Detalles Bibliográficos
Autores principales: Fajas, L., Lopez-Mejia, I. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154832/
https://www.ncbi.nlm.nih.gov/pubmed/30263936
http://dx.doi.org/10.1080/23723556.2017.1409862
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author Fajas, L.
Lopez-Mejia, I. C.
author_facet Fajas, L.
Lopez-Mejia, I. C.
author_sort Fajas, L.
collection PubMed
description Cyclin-dependent kinase 4 (CDK4) is a positive regulator of cell cycle progression, however, there is growing evidence demonstrating that its function exceeds the control of cell division. Here we show that CDK4 is an important regulator of cellular substrate utilization through direct inhibition of the metabolic regulator AMPK (AMP-activated protein kinase).
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spelling pubmed-61548322019-05-16 CDK4, a new metabolic sensor that antagonizes AMPK Fajas, L. Lopez-Mejia, I. C. Mol Cell Oncol Commentary Cyclin-dependent kinase 4 (CDK4) is a positive regulator of cell cycle progression, however, there is growing evidence demonstrating that its function exceeds the control of cell division. Here we show that CDK4 is an important regulator of cellular substrate utilization through direct inhibition of the metabolic regulator AMPK (AMP-activated protein kinase). Taylor & Francis 2018-05-16 /pmc/articles/PMC6154832/ /pubmed/30263936 http://dx.doi.org/10.1080/23723556.2017.1409862 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Fajas, L.
Lopez-Mejia, I. C.
CDK4, a new metabolic sensor that antagonizes AMPK
title CDK4, a new metabolic sensor that antagonizes AMPK
title_full CDK4, a new metabolic sensor that antagonizes AMPK
title_fullStr CDK4, a new metabolic sensor that antagonizes AMPK
title_full_unstemmed CDK4, a new metabolic sensor that antagonizes AMPK
title_short CDK4, a new metabolic sensor that antagonizes AMPK
title_sort cdk4, a new metabolic sensor that antagonizes ampk
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154832/
https://www.ncbi.nlm.nih.gov/pubmed/30263936
http://dx.doi.org/10.1080/23723556.2017.1409862
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