CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health

ER stress-mediated induction of a new vertebrate-specific autophagy cargo receptor, CCPG1 (cell-cycle progression gene 1), drives degradation of endoplasmic reticulum. CCPG1 acts via ATG8-family interaction and, non-canonically, via discrete interactions with FIP200. CCPG1 ameliorates ER stress in t...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Matthew D., Wilkinson, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154861/
https://www.ncbi.nlm.nih.gov/pubmed/30263939
http://dx.doi.org/10.1080/23723556.2018.1441631
_version_ 1783357773725040640
author Smith, Matthew D.
Wilkinson, Simon
author_facet Smith, Matthew D.
Wilkinson, Simon
author_sort Smith, Matthew D.
collection PubMed
description ER stress-mediated induction of a new vertebrate-specific autophagy cargo receptor, CCPG1 (cell-cycle progression gene 1), drives degradation of endoplasmic reticulum. CCPG1 acts via ATG8-family interaction and, non-canonically, via discrete interactions with FIP200. CCPG1 ameliorates ER stress in the exocrine pancreas. This has potential implications for inflammation and cancer, discussed here.
format Online
Article
Text
id pubmed-6154861
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-61548612019-08-23 CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health Smith, Matthew D. Wilkinson, Simon Mol Cell Oncol Author's Views ER stress-mediated induction of a new vertebrate-specific autophagy cargo receptor, CCPG1 (cell-cycle progression gene 1), drives degradation of endoplasmic reticulum. CCPG1 acts via ATG8-family interaction and, non-canonically, via discrete interactions with FIP200. CCPG1 ameliorates ER stress in the exocrine pancreas. This has potential implications for inflammation and cancer, discussed here. Taylor & Francis 2018-08-23 /pmc/articles/PMC6154861/ /pubmed/30263939 http://dx.doi.org/10.1080/23723556.2018.1441631 Text en © 2018 Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Smith, Matthew D.
Wilkinson, Simon
CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health
title CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health
title_full CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health
title_fullStr CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health
title_full_unstemmed CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health
title_short CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health
title_sort ccpg1, an unconventional cargo receptor for er-phagy, maintains pancreatic acinar cell health
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154861/
https://www.ncbi.nlm.nih.gov/pubmed/30263939
http://dx.doi.org/10.1080/23723556.2018.1441631
work_keys_str_mv AT smithmatthewd ccpg1anunconventionalcargoreceptorforerphagymaintainspancreaticacinarcellhealth
AT wilkinsonsimon ccpg1anunconventionalcargoreceptorforerphagymaintainspancreaticacinarcellhealth

Ejemplares similares