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Fast design of arbitrary length loops in proteins using InteractiveRosetta

BACKGROUND: With increasing interest in ab initio protein design, there is a desire to be able to fully explore the design space of insertions and deletions. Nature inserts and deletes residues to optimize energy and function, but allowing variable length indels in the context of an interactive prot...

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Detalles Bibliográficos
Autores principales: Hooper, William F., Walcott, Benjamin D., Wang, Xing, Bystroff, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154894/
https://www.ncbi.nlm.nih.gov/pubmed/30249181
http://dx.doi.org/10.1186/s12859-018-2345-5