Cargando…
The potential HLA Class I-restricted epitopes derived from LeIF and TSA of Leishmania donovani evoke anti-leishmania CD8+ T lymphocyte response
To explore new protective measure against visceral leishmaniasis, reverse vaccinology approach was employed to identify key immunogenic regions which can mediate long-term immunity. In-depth computational analysis revealed nine promiscuous epitopes which can possibly be presented by 46 human leukocy...
Autores principales: | Dikhit, Manas Ranjan, Das, Sushmita, Mahantesh, Vijaya, Kumar, Akhilesh, Singh, Ashish Kumar, Dehury, Budheswar, Rout, Ajaya Kumar, Ali, Vahab, Sahoo, Ganesh Chandra, Topno, Roshan Kamal, Pandey, Krishna, Das, V. N. R., Bimal, Sanjiva, Das, Pradeep |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154976/ https://www.ncbi.nlm.nih.gov/pubmed/30242172 http://dx.doi.org/10.1038/s41598-018-32040-x |
Ejemplares similares
-
Identification of Potential MHC Class-II-Restricted Epitopes Derived from Leishmania donovani Antigens by Reverse Vaccinology and Evaluation of Their CD4+ T-Cell Responsiveness against Visceral Leishmaniasis
por: Dikhit, Manas Ranjan, et al.
Publicado: (2017) -
Leishmania donovani Secretory Mevalonate Kinase Regulates Host Immune Response and Facilitates Phagocytosis
por: Bamra, Tanvir, et al.
Publicado: (2021) -
Identification of Leishmania donovani antigen in circulating immune complexes of visceral leishmaniasis subjects for diagnosis
por: Jamal, Fauzia, et al.
Publicado: (2017) -
Intracellular zinc flux causes reactive oxygen species mediated mitochondrial dysfunction leading to cell death in Leishmania donovani
por: Kumari, Anjali, et al.
Publicado: (2017) -
Differential Regulation of miRNA Profiles of Human Cells Experimentally Infected by Leishmania donovani Isolated From Indian Visceral Leishmaniasis and Post-Kala-Azar Dermal Leishmaniasis
por: Kumar, Ashish, et al.
Publicado: (2020)