Chemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin

Cancer-induced blood coagulation in human tumour generates insoluble fibrin (IF)-rich cancer stroma in which uneven monoclonal antibody (mAb) distribution reduce the potential effectiveness of mAb-mediated treatments. Previously, we developed a mAb that reacts only with IF and not with fibrinogen (F...

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Detalles Bibliográficos
Autores principales: Fuchigami, Hirobumi, Manabe, Shino, Yasunaga, Masahiro, Matsumura, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155080/
https://www.ncbi.nlm.nih.gov/pubmed/30242282
http://dx.doi.org/10.1038/s41598-018-32601-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155080/
https://www.ncbi.nlm.nih.gov/pubmed/30242282
http://dx.doi.org/10.1038/s41598-018-32601-0

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