Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma

Mitochondria are central key players in cell metabolism, and mitochondrial DNA (mtDNA) instability has been linked to metabolic changes that contribute to tumorigenesis and to increased expression of pro-tumorigenic genes. Here, we use melanoma cell lines and metastatic melanoma tumors to evaluate t...

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Detalles Bibliográficos
Autores principales: Araujo, L. F., Siena, A. D. D., Plaça, J. R., Brotto, D. B., Barros, I. I., Muys, B. R., Biagi, C. A. O., Peronni, K. C., Sousa, J. F., Molfetta, G. A., West, L. C., West, A. P., Leopoldino, A. M., Espreafico, E. M., Silva, W. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155108/
https://www.ncbi.nlm.nih.gov/pubmed/30242167
http://dx.doi.org/10.1038/s41598-018-31170-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155108/
https://www.ncbi.nlm.nih.gov/pubmed/30242167
http://dx.doi.org/10.1038/s41598-018-31170-6

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