Cargando…

Parkin-dependent regulation of the MCU complex component MICU1

The mitochondrial Ca(2+) uniporter machinery is a multiprotein complex composed by the Ca(2+) selective pore-forming subunit, the mitochondrial uniporter (MCU), and accessory proteins, including MICU1, MICU2 and EMRE. Their concerted action is required to fine-tune the uptake of Ca(2+) into the mito...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matteucci, Alessandra, Patron, Maria, Vecellio Reane, Denis, Gastaldello, Stefano, Amoroso, Salvatore, Rizzuto, Rosario, Brini, Marisa, Raffaello, Anna, Calì, Tito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155109/ https://www.ncbi.nlm.nih.gov/pubmed/30242232 http://dx.doi.org/10.1038/s41598-018-32551-7

Ejemplares similares

Publisher Correction: Parkin-dependent regulation of the MCU complex component MICU1
por: Matteucci, Alessandra, et al.
Publicado: (2019)

MICU1 and MICU2 Finely Tune the Mitochondrial Ca(2+) Uniporter by Exerting Opposite Effects on MCU Activity
por: Patron, Maria, et al.
Publicado: (2014)

The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation
por: Vecellio Reane, Denis, et al.
Publicado: (2022)

Structure of intact human MCU supercomplex with the auxiliary MICU subunits
por: Zhuo, Wei, et al.
Publicado: (2020)

Crosstalk between Calcium and ROS in Pathophysiological Conditions
por: Feno, Simona, et al.
Publicado: (2019)

Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2+)
por: Waldeck-Weiermair, Markus, et al.
Publicado: (2015)

Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models
por: Mammucari, Cristina, et al.
Publicado: (2018)

PINK1/Parkin Mediated Mitophagy, Ca(2+) Signalling, and ER–Mitochondria Contacts in Parkinson’s Disease
por: Barazzuol, Lucia, et al.
Publicado: (2020)

The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex
por: Phillips, Charles B, et al.
Publicado: (2019)

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca(2+) Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU
por: Paillard, Melanie, et al.
Publicado: (2017)

Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake
por: Butera, Gaia, et al.
Publicado: (2021)

SEPSIS LEADS TO IMPAIRED MITOCHONDRIAL CALCIUM UPTAKE AND SKELETAL MUSCLE WEAKNESS BY REDUCING THE MICU1:MCU PROTEIN RATIO
por: Li, Xuexin, et al.
Publicado: (2023)

The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human Diseases
por: D’Angelo, Donato, et al.
Publicado: (2023)

Gene expression changes of single skeletal muscle fibers in response to modulation of the mitochondrial calcium uniporter (MCU)
por: Chemello, Francesco, et al.
Publicado: (2015)

Mitochondrial Ca(2+) and neurodegeneration
por: Calì, Tito, et al.
Publicado: (2012)

Mitochondrial Ca(2+) Uptake 1 (MICU1) and Mitochondrial Ca(2+) Uniporter (MCU) Contribute to Metabolism-Secretion Coupling in Clonal Pancreatic β-Cells
por: Alam, Muhammad Rizwan, et al.
Publicado: (2012)

A High-Throughput Screening Identifies MICU1 Targeting Compounds
por: Di Marco, Giulia, et al.
Publicado: (2020)

Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2
por: Wang, Chongyuan, et al.
Publicado: (2020)

Structure of the MICU1–MICU2 heterodimer provides insights into the gatekeeping threshold shift
por: Park, Jongseo, et al.
Publicado: (2020)

Calcium, Dopamine and Neuronal Calcium Sensor 1: Their Contribution to Parkinson’s Disease
por: Catoni, Cristina, et al.
Publicado: (2019)

Get Closer to the World of Contact Sites: A Beginner's Guide to Proximity-Driven Fluorescent Probes
por: Poggio, Elena, et al.
Publicado: (2022)

Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter
por: De Mario, Agnese, et al.
Publicado: (2021)

The Mitochondrial Ca(2+) Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells
por: Tarasov, Andrei I., et al.
Publicado: (2012)

MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells
por: Panahi, Ghodratollah, et al.
Publicado: (2018)

The Close Encounter Between Alpha-Synuclein and Mitochondria
por: Vicario, Mattia, et al.
Publicado: (2018)

ER–Mitochondria Contact Sites Reporters: Strengths and Weaknesses of the Available Approaches
por: Giamogante, Flavia, et al.
Publicado: (2020)

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling
por: Plovanich, Molly, et al.
Publicado: (2013)

Excessive Accumulation of Ca(2 +) in Mitochondria of Y522S-RYR1 Knock-in Mice: A Link Between Leak From the Sarcoplasmic Reticulum and Altered Redox State
por: Canato, Marta, et al.
Publicado: (2019)

Expression and preliminary characterization of human MICU2
por: Li, Dan, et al.
Publicado: (2016)

MICU1- Related Myopathy with Extrapyramidal Signs
por: Mukherjee, Debaleena, et al.
Publicado: (2023)

Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane
por: Bondarenko, Alexander I., et al.
Publicado: (2013)

Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood
por: Lewis-Smith, David, et al.
Publicado: (2016)

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca(2+) Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi
por: Bertolini, Mayara S., et al.
Publicado: (2019)

The Function of Mitochondrial Calcium Uniporter at the Whole-Cell and Single Mitochondrion Levels in WT, MICU1 KO, and MICU2 KO Cells
por: Shah, Syed Islamuddin, et al.
Publicado: (2020)

Different Sensitivity of Control and MICU1- and MICU2-Ablated Trypanosoma cruzi Mitochondrial Calcium Uniporter Complex to Ruthenium-Based Inhibitors
por: Bertolini, Mayara S., et al.
Publicado: (2020)

MCU knockdown in hippocampal neurons improves memory performance of an Alzheimer’s disease mouse model : MCU knockdown improves memory performance
por: Cai, Hongyan, et al.
Publicado: (2022)

MICU1 drives glycolysis and chemoresistance in ovarian cancer
por: Chakraborty, Prabir K., et al.
Publicado: (2017)

splitGFP Technology Reveals Dose-Dependent ER-Mitochondria Interface Modulation by α-Synuclein A53T and A30P Mutants
por: Calì, Tito, et al.
Publicado: (2019)

Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells
por: Watanabe, Akira, et al.
Publicado: (2022)

Stable Integration of Inducible SPLICS Reporters Enables Spatio-Temporal Analysis of Multiple Organelle Contact Sites upon Modulation of Cholesterol Traffic
por: Giamogante, Flavia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_07g02bapvn5t38jhq8h742fvda