A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

Epidermal growth factor receptor (EGFR) activation by growth factors (GFs) relies on dimerization and allosteric activation of its intrinsic kinase activity, resulting in trans-phosphorylation of tyrosines on its C-terminal tail. While structural and biochemical studies identified this EGF-induced a...

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Detalles Bibliográficos
Autores principales: Baumdick, Martin, Gelléri, Márton, Uttamapinant, Chayasith, Beránek, Václav, Chin, Jason W., Bastiaens, Philippe I. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155120/
https://www.ncbi.nlm.nih.gov/pubmed/30242154
http://dx.doi.org/10.1038/s41467-018-06299-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155120/
https://www.ncbi.nlm.nih.gov/pubmed/30242154
http://dx.doi.org/10.1038/s41467-018-06299-7

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