PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair

PAXX is a recently identified component of the nonhomologous end joining (NHEJ) DNA repair pathway. The molecular mechanisms of PAXX action remain largely unclear. Here we characterise the interactomes of PAXX and its paralogs, XLF and XRCC4, to show that these factors share the ability to interact...

Descripción completa

Detalles Bibliográficos
Autores principales: Craxton, Andrew, Munnur, Deeksha, Jukes-Jones, Rebekah, Skalka, George, Langlais, Claudia, Cain, Kelvin, Malewicz, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155126/
https://www.ncbi.nlm.nih.gov/pubmed/30250067
http://dx.doi.org/10.1038/s41467-018-06127-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155126/
https://www.ncbi.nlm.nih.gov/pubmed/30250067
http://dx.doi.org/10.1038/s41467-018-06127-y

Ejemplares similares