A novel human IL-2 mutein with minimal systemic toxicity exerts greater antitumor efficacy than wild-type IL-2

IL-2 is critical to the activation, growth, and survival of T cells and NK cells, and maintains the delicate balance between auto-immunity and anti-neoplasm surveillance. High IL-2 doses have clear antitumor capabilities, but also have severe side effects that limit its clinical use. Side effects in...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Ai, Xiaojie, Wu, Chunlian, Wang, Heyong, Zeng, Gang, Yang, Peixin, Liu, Gentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155133/
https://www.ncbi.nlm.nih.gov/pubmed/30250191
http://dx.doi.org/10.1038/s41419-018-1047-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155133/
https://www.ncbi.nlm.nih.gov/pubmed/30250191
http://dx.doi.org/10.1038/s41419-018-1047-2

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