Malic Enzyme 1 (ME1) is pro-oncogenic in Apc(Min/+) mice

Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with Apc(Min/+) mice to obtain male Apc(...

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Detalles Bibliográficos
Autores principales: Fernandes, Lorenzo M., Al-Dwairi, Ahmed, Simmen, Rosalia C. M., Marji, Meera, Brown, Dustin M., Jewell, Sarah W., Simmen, Frank A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155149/
https://www.ncbi.nlm.nih.gov/pubmed/30250042
http://dx.doi.org/10.1038/s41598-018-32532-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155149/
https://www.ncbi.nlm.nih.gov/pubmed/30250042
http://dx.doi.org/10.1038/s41598-018-32532-w

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