PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein

The tumor suppressor Hippo pathway negatively regulates the transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) to inhibit cell growth and control organ size, whereas activation of YAP and TAZ is implicated in tumorigenesis and cance...

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Detalles Bibliográficos
Autores principales: Kedan, Amir, Verma, Nandini, Saroha, Ashish, Shreberk-Shaked, Michal, Müller, Anna-Katharina, Nair, Nishanth Ulhas, Lev, Sima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155151/
https://www.ncbi.nlm.nih.gov/pubmed/30250159
http://dx.doi.org/10.1038/s41419-018-1005-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155151/
https://www.ncbi.nlm.nih.gov/pubmed/30250159
http://dx.doi.org/10.1038/s41419-018-1005-z

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