Excited-State Dynamics of the Thiopurine Prodrug 6-Thioguanine: Can N9-Glycosylation Affect Its Phototoxic Activity?

6-Thioguanine, an immunosuppressant and anticancer prodrug, has been shown to induce DNA damage and cell death following exposure to UVA radiation. Its metabolite, 6-thioguanosine, plays a major role in the prodrug’s overall photoreactivity. However, 6-thioguanine itself has proven to be cytotoxic f...

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Detalles Bibliográficos
Autores principales: Ashwood, Brennan, Jockusch, Steffen, Crespo-Hernández, Carlos E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155220/
https://www.ncbi.nlm.nih.gov/pubmed/28264514
http://dx.doi.org/10.3390/molecules22030379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155220/
https://www.ncbi.nlm.nih.gov/pubmed/28264514
http://dx.doi.org/10.3390/molecules22030379

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