Cargando…

Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, fro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rioton, Sarah, Pardo, Domingo Gomez, Cossy, Janine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155269/ https://www.ncbi.nlm.nih.gov/pubmed/28335499 http://dx.doi.org/10.3390/molecules22030483

Ejemplares similares

Sigmatropic rearrangements of cyclopropenylcarbinol derivatives. Access to diversely substituted alkylidenecyclopropanes
por: Ernouf, Guillaume, et al.
Publicado: (2019)

Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones
por: Ma, Ransong, et al.
Publicado: (2022)

Trifluoromethyl-substituted tetrathiafulvalenes
por: Jeannin, Olivier, et al.
Publicado: (2015)

Synthesis of Aminoethyl‐Substituted Piperidine Derivatives as σ(1) Receptor Ligands with Antiproliferative Properties
por: Holtschulte, Catharina, et al.
Publicado: (2022)

Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis
por: Mlostoń, Grzegorz, et al.
Publicado: (2010)

An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars
por: Zhao, Hui, et al.
Publicado: (2013)

Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications
por: Frolov, Nikita A., et al.
Publicado: (2023)

Design, Synthesis, and Antibacterial and Antifungal Activities of Novel Trifluoromethyl and Trifluoromethoxy Substituted Chalcone Derivatives
por: Lagu, Surendra Babu, et al.
Publicado: (2020)

Synthesis and Solvent Dependent Fluorescence of Some Piperidine-Substituted Naphthalimide Derivatives and Consequences for Water Sensing
por: Tigoianu, Radu, et al.
Publicado: (2022)

Synthesis of 5,10-bis(Trifluoromethyl) Substituted β-Octamethylporphyrins and Central-Metal-Dependent Solvolysis of Their meso-Trifluoromethyl Groups
por: Suzuki, Masaaki, et al.
Publicado: (2016)

Synthesis of α,γ-Chiral Trifluoromethylated Amines through the Stereospecific Isomerization of α-Chiral Allylic Amines
por: García-Vázquez, Víctor, et al.
Publicado: (2022)

Single enantiomer synthesis of α-(trifluoromethyl)-β-lactam
por: Jurčík, Václav, et al.
Publicado: (2011)

[Co(TPP)]‐Catalyzed Formation of Substituted Piperidines
por: Lankelma, Marianne, et al.
Publicado: (2019)

A flow electrochemistry‐enabled synthesis of 2‐substituted N‐(methyl‐d)piperidines
por: AL‐Hadedi, Azzam A. M., et al.
Publicado: (2022)

Enantio-Complementary Synthesis of 2-Substituted Pyrrolidines and Piperidines via Transaminase-Triggered Cyclizations
por: Heckmann, Christian M., et al.
Publicado: (2023)

A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons
por: Huang, Xiongyi, et al.
Publicado: (2019)

Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria
por: Alkhaibari, Ibrahim S., et al.
Publicado: (2021)

Trifluoromethyl ethers – synthesis and properties of an unusual substituent
por: Leroux, Frédéric R, et al.
Publicado: (2008)

Controllable Synthesis of Trifluoromethyl- or gem-Difluorovinyl-containing Analogues of Neonicotinoids by the Reaction of α-(Trifluoromethyl)styrenes with 2-Nitroimino-imidazolidine
por: He, Jingjing, et al.
Publicado: (2023)

Synthesis and Evaluation of a Series of 2-Substituted-5-Thiopropylpiperazine (Piperidine)-1,3,4-Oxadiazoles Derivatives as Atypical Antipsychotics
por: Chen, Yin, et al.
Publicado: (2012)

Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
por: Seck, Rokhyatou, et al.
Publicado: (2020)

Gold(I) α‐Trifluoromethyl Carbenes: Synthesis, Characterization and Reactivity Studies
por: Rigoulet, Mathilde, et al.
Publicado: (2022)

Novel Synthesis of Substituted 2-Trifluoromethyl and 2-Perfluoroalkyl N-Arylpyridinium Compounds—Mechanistic Insights
por: El Kharrat, Salem, et al.
Publicado: (2019)

Design and Synthesis of Novel 5-((3-(Trifluoromethyl)piperidin-1-yl)sulfonyl)indoline-2,3-dione Derivatives as Promising Antiviral Agents: In Vitro, In Silico, and Structure–Activity Relationship Studies
por: Ezz Eldin, Rogy R., et al.
Publicado: (2023)

Diastereoselective synthesis of new zwitterionic bicyclic lactams, scaffolds for construction of 2-substituted-4-hydroxy piperidine and its pipecolic acid derivatives
por: Reyes-Bravo, Enrique, et al.
Publicado: (2022)

Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α-Peptoids) and Derivatives
por: Culf, Adrian S., et al.
Publicado: (2010)

Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
por: Wu, Zhibing, et al.
Publicado: (2012)

Aluminum-catalyzed tunable halodefluorination of trifluoromethyl- and difluoroalkyl-substituted olefins
por: Liu, Zhong, et al.
Publicado: (2020)

Crystal structure of (4-hydroxypiperidin-1-yl)[4-(trifluoromethyl)phenyl]methanone
por: Revathi, B. K., et al.
Publicado: (2015)

Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines – sequential versus multicomponent reaction approach
por: Palka, Barbara, et al.
Publicado: (2014)

Immobilization of Trifluoromethyl-Substituted Pyridine-Oxazoline Ligand and Its Application in Asymmetric Continuous Flow Synthesis of Benzosultams
por: Kocúrik, Martin, et al.
Publicado: (2023)

A “Broad Spectrum” Carbene Transferase for Synthesis of Chiral α-Trifluoromethylated Organoborons
por: Alonso-Cotchico, Lur, et al.
Publicado: (2019)

Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16
por: Zhang, Xian, et al.
Publicado: (2013)

Photosensitized direct C–H fluorination and trifluoromethylation in organic synthesis
por: Yakubov, Shahboz, et al.
Publicado: (2020)

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime
por: Gonçalves, Raoni S B, et al.
Publicado: (2013)

Synthesis of Trifluoromethylated Monoterpene Amino Alcohols
por: Petrova, Polina A., et al.
Publicado: (2022)

Design, Synthesis, and Fungicidal Activity of Novel Thiosemicarbazide Derivatives Containing Piperidine Fragments
por: Zhang, Xuebo, et al.
Publicado: (2017)

Functionalization of Piperidine Derivatives for the Site‐Selective and Stereoselective Synthesis of Positional Analogues of Methylphenidate
por: Liu, Wenbin, et al.
Publicado: (2020)

Direct Synthesis of α‐Aryl‐α‐Trifluoromethyl Alcohols via Nickel Catalyzed Cross‐Electrophile Coupling
por: Lombardi, Lorenzo, et al.
Publicado: (2022)

Investigation on the reactivity of α-azidochalcones with carboxylic acids: Formation of α-amido-1,3-diketones and highly substituted 2-(trifluoromethyl)oxazoles
por: Rajaguru, Kandasamy, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_cki3903p629dmiv5lof3jcpbkb