Cargando…

Luteolin Inhibits Fibrillary β-Amyloid(1–40)-Induced Inflammation in a Human Blood-Brain Barrier Model by Suppressing the p38 MAPK-Mediated NF-κB Signaling Pathways

Amyloid-β peptides (Aβ) exist in several forms and are known as key modulators of Alzheimer’s disease (AD). Fibrillary Aβ (fAβ) has been found to disrupt the blood-brain barrier (BBB) by triggering and promoting inflammation. In this study, luteolin, a naturally occurring flavonoid that has shown be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jun-Xia, Xing, Jian-Guo, Wang, Lin-Lin, Jiang, Hai-Lun, Guo, Shui-Long, Liu, Rui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155314/ https://www.ncbi.nlm.nih.gov/pubmed/28245546 http://dx.doi.org/10.3390/molecules22030334

Ejemplares similares

Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid-β (1−40)Injury by Suppressing the MAPK/NF-κB Inflammatory Pathways
por: Liu, Rui, et al.
Publicado: (2014)

Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways
por: Huang, Wen-Chung, et al.
Publicado: (2020)

Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-κB and P38 MAPK Signaling Pathways
por: Hu, Xuantao, et al.
Publicado: (2020)

Luteolin Isolated from the Flowers of Lonicera japonica Suppresses Inflammatory Mediator Release by Blocking NF-κB and MAPKs Activation Pathways in HMC-1 Cells
por: Kang, Ok-Hwa, et al.
Publicado: (2010)

Downregulation of cathepsin C alleviates endothelial cell dysfunction by suppressing p38 MAPK/NF-κB pathway in preeclampsia
por: Lu, Fan, et al.
Publicado: (2022)

Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-κB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma
por: Yan, Guang Hai, et al.
Publicado: (2014)

Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss
por: Xu, Shenggui, et al.
Publicado: (2021)

Combination of plasma amyloid beta((1-42/1-40)) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology
por: Verberk, Inge M. W., et al.
Publicado: (2020)

Luteolin reduces inflammation in Staphylococcus aureus-induced mastitis by inhibiting NF-κB activation and MMPs expression
por: Guo, Ying-fang, et al.
Publicado: (2017)

MKP-3 suppresses LPS-induced inflammatory responses in HUVECs via inhibition of p38 MAPK/NF-κB pathway
por: Unenkhuu, Banzragchgarav, et al.
Publicado: (2021)

Chlorogenic acid rich in coffee pulp extract suppresses inflammatory status by inhibiting the p38, MAPK, and NF-κB pathways
por: Ontawong, Atcharaporn, et al.
Publicado: (2023)

Adiporedoxin suppresses endothelial activation via inhibiting MAPK and NF-κB signaling
por: He, Hui, et al.
Publicado: (2016)

Role of GABA(B) receptors and p38MAPK/NF-κB pathway in paclitaxel-induced apoptosis of hippocampal neurons
por: Li, Zhao, et al.
Publicado: (2017)

Epac‐2 ameliorates spontaneous colitis in Il‐10 (−/−) mice by protecting the intestinal barrier and suppressing NF‐κB/MAPK signalling
por: Song, Xue, et al.
Publicado: (2021)

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-κB
por: Huang, Xia, et al.
Publicado: (2017)

Lidocaine relieves murine allergic rhinitis by regulating the NF-κB and p38 MAPK pathways
por: Xiang, Jing, et al.
Publicado: (2022)

Koumine Promotes ROS Production to Suppress Hepatocellular Carcinoma Cell Proliferation Via NF-κB and ERK/p38 MAPK Signaling
por: Yuan, Zhihang, et al.
Publicado: (2019)

Malonic acid suppresses lipopolysaccharide-induced BV2 microglia cell activation by inhibiting the p38 MAPK/NF-κB pathway
por: Lee, Hana, et al.
Publicado: (2021)

Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier
por: Griffin, Jarred M., et al.
Publicado: (2016)

FJU‐C28 inhibits the endotoxin‐induced pro‐inflammatory cytokines expression via suppressing JNK, p38 MAPK and NF‐κB signaling pathways
por: Jung, Fang, et al.
Publicado: (2021)

Ergosterol peroxide exhibits antiviral and immunomodulatory abilities against porcine deltacoronavirus (PDCoV) via suppression of NF-κB and p38/MAPK signaling pathways in vitro
por: Duan, Cong, et al.
Publicado: (2021)

Luteolin-3′-O-Phosphate Inhibits Lipopolysaccharide-Induced Inflammatory Responses by Regulating NF-κB/MAPK Cascade Signaling in RAW 264.7 Cells
por: Kim, Jung-Hwan, et al.
Publicado: (2021)

Luteolin suppresses tumor proliferation through inducing apoptosis and autophagy via MAPK activation in glioma
por: You, Yijie, et al.
Publicado: (2019)

A Newly Synthesized Flavone from Luteolin Escapes from COMT-Catalyzed Methylation and Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages via JNK, p38 and NF-κB Signaling Pathways
por: Ye, Lin, et al.
Publicado: (2022)

Effects of Tianxiangdan Granule treatment on atherosclerosis via NF-κB and p38 MAPK signaling pathways
por: Sun, Long-Fei, et al.
Publicado: (2018)

Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice
por: Li, Yi-Ching, et al.
Publicado: (2012)

Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages
por: Chen, Chiu-Yuan, et al.
Publicado: (2007)

Salidroside protects against intestinal barrier dysfunction in septic mice by regulating IL‑17 to block the NF‑κB and p38 MAPK signaling pathways
por: Liao, Rongxin, et al.
Publicado: (2023)

Serum amyloid A inhibits astrocyte migration via activating p38 MAPK
por: Lin, Aihua, et al.
Publicado: (2020)

Luo Tong formula attenuates retinal inflammation in diabetic rats via inhibition of the p38MAPK/NF-κB pathway
por: Pang, Bing, et al.
Publicado: (2020)

Magnoflorine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Suppressing NF-κB and MAPK Activation
por: Guo, Shuai, et al.
Publicado: (2018)

Neobavaisoflavone ameliorates LPS-induced RAW264.7 cell inflammations by suppressing the activation of NF-κB and MAPKs signaling pathways
por: Yuan, Qing, et al.
Publicado: (2022)

Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-κB
por: Quan, Gui-Hua, et al.
Publicado: (2015)

Artemisia gmelinii Attenuates Lung Inflammation by Suppressing the NF-κB/MAPK Pathway
por: Kim, Seung Yong, et al.
Publicado: (2022)

Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity
por: Mo, Wenhui, et al.
Publicado: (2018)

Wang-Bi Tablet Ameliorates DMM-Induced Knee Osteoarthritis through Suppressing the Activation of p38-MAPK and NF-κB Signaling Pathways in Mice
por: Li, Hui, et al.
Publicado: (2021)

Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway
por: Fu, Wei, et al.
Publicado: (2022)

Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
por: Wang, Heng, et al.
Publicado: (2023)

Luteolin suppresses TNF-α-induced inflammatory injury and senescence of nucleus pulposus cells via the Sirt6/NF-κB pathway
por: Xie, Tian, et al.
Publicado: (2022)

PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF‐κB signaling
por: Yang, Xinyi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hjk28ib9e45rb78j2ef0v29qha