Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1

Traumatic brain injury (TBI) elevates Abeta (Aβ) peptides in the brain and cerebral spinal fluid. Aβ peptides are amphipathic molecules that can modulate membrane mechanics. Because the mechanosensitive cation channel PIEZO1 is gated by membrane tension and curvature, it prompted us to test the effe...

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Detalles Bibliográficos
Autores principales: Maneshi, Mohammad M., Ziegler, Lynn, Sachs, Frederick, Hua, Susan Z., Gottlieb, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155315/
https://www.ncbi.nlm.nih.gov/pubmed/30250223
http://dx.doi.org/10.1038/s41598-018-32572-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155315/
https://www.ncbi.nlm.nih.gov/pubmed/30250223
http://dx.doi.org/10.1038/s41598-018-32572-2

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