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Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells

The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting tha...

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Detalles Bibliográficos
Autores principales: Vattulainen-Collanus, Sanna, Southwood, Mark, Yang, Xu Dong, Moore, Stephen, Ghatpande, Prajakta, Morrell, Nicholas W., Lagna, Giorgio, Hata, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155317/
https://www.ncbi.nlm.nih.gov/pubmed/30272025
http://dx.doi.org/10.1038/s42003-018-0152-1