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Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time

The Keap1-Nrf2 system is an evolutionarily conserved defense mechanism against oxidative and xenobiotic stress. Its regulatory mechanisms, e.g., stress-sensing mechanism, proteasome-based regulation of Nrf2 activity and selection of target genes, have been elucidated mainly in mammals. In addition,...

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Detalles Bibliográficos
Autores principales: Fuse, Yuji, Kobayashi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155405/
https://www.ncbi.nlm.nih.gov/pubmed/28282941
http://dx.doi.org/10.3390/molecules22030436