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Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time
The Keap1-Nrf2 system is an evolutionarily conserved defense mechanism against oxidative and xenobiotic stress. Its regulatory mechanisms, e.g., stress-sensing mechanism, proteasome-based regulation of Nrf2 activity and selection of target genes, have been elucidated mainly in mammals. In addition,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155405/ https://www.ncbi.nlm.nih.gov/pubmed/28282941 http://dx.doi.org/10.3390/molecules22030436 |