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Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability
Genomic instability is a major driver of intra-tumor heterogeneity. However, unstable genomes often exhibit different molecular and clinical phenotypes, which are associated with distinct mutational processes. Here, we algorithmically inferred the clonal phylogenies of ~6,000 human tumors from 32 tu...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155543/ https://www.ncbi.nlm.nih.gov/pubmed/30212491 http://dx.doi.org/10.1371/journal.pgen.1007669 |