Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli

The DNA ligases, enzymes that seal breaks in the backbones of DNA, are essential for all organisms, however bacterial ligases essential for DNA replication use β-nicotinamide adenine dinucleotide as their co-factor, whereas those that are essential in eukaryotes and viruses use adenosine-5′-triphosp...

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Detalles Bibliográficos
Autores principales: Korycka-Machala, Malgorzata, Nowosielski, Marcin, Kuron, Aneta, Rykowski, Sebastian, Olejniczak, Agnieszka, Hoffmann, Marcin, Dziadek, Jaroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155577/
https://www.ncbi.nlm.nih.gov/pubmed/28106753
http://dx.doi.org/10.3390/molecules22010154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155577/
https://www.ncbi.nlm.nih.gov/pubmed/28106753
http://dx.doi.org/10.3390/molecules22010154

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