Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties

With the aim of increasing the structural diversity on the early antimalarial drug plasmodione, an efficient and versatile procedure to prepare a series of biaryl- and N-arylalkylamines as plasmodione analogues is described. Using the naturally occurring and commercially available menadione as start...

Descripción completa

Detalles Bibliográficos
Autores principales: Urgin, Karène, Jida, Mouhamad, Ehrhardt, Katharina, Müller, Tobias, Lanzer, Michael, Maes, Louis, Elhabiri, Mourad, Davioud-Charvet, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155649/
https://www.ncbi.nlm.nih.gov/pubmed/28106855
http://dx.doi.org/10.3390/molecules22010161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155649/
https://www.ncbi.nlm.nih.gov/pubmed/28106855
http://dx.doi.org/10.3390/molecules22010161

Ejemplares similares