Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

Chagas disease or American trypanosomiasis is a worldwide public health problem. In this work, we evaluated 26 new propyl and isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential trypanocidal agents. Additionally, molecular docking and enzymatic assays on trypanothione reducta...

Descripción completa

Detalles Bibliográficos
Autores principales: Chacón-Vargas, Karla Fabiola, Nogueda-Torres, Benjamin, Sánchez-Torres, Luvia E., Suarez-Contreras, Erick, Villalobos-Rocha, Juan Carlos, Torres-Martinez, Yuridia, Lara-Ramirez, Edgar E., Fiorani, Giulia, Krauth-Siegel, R. Luise, Bolognesi, Maria Laura, Monge, Antonio, Rivera, Gildardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155662/
https://www.ncbi.nlm.nih.gov/pubmed/28157150
http://dx.doi.org/10.3390/molecules22020220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155662/
https://www.ncbi.nlm.nih.gov/pubmed/28157150
http://dx.doi.org/10.3390/molecules22020220

Ejemplares similares