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Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

Chagas disease or American trypanosomiasis is a worldwide public health problem. In this work, we evaluated 26 new propyl and isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential trypanocidal agents. Additionally, molecular docking and enzymatic assays on trypanothione reducta...

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Detalles Bibliográficos
Autores principales:	Chacón-Vargas, Karla Fabiola, Nogueda-Torres, Benjamin, Sánchez-Torres, Luvia E., Suarez-Contreras, Erick, Villalobos-Rocha, Juan Carlos, Torres-Martinez, Yuridia, Lara-Ramirez, Edgar E., Fiorani, Giulia, Krauth-Siegel, R. Luise, Bolognesi, Maria Laura, Monge, Antonio, Rivera, Gildardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155662/ https://www.ncbi.nlm.nih.gov/pubmed/28157150 http://dx.doi.org/10.3390/molecules22020220

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