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Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects
Modular polyketide synthases (mPKSs) build functionalized polymeric chains, some of which have become blockbuster therapeutics. Organized into repeating clusters (modules) of independently-folding domains, these assembly-line-like megasynthases can be engineered by introducing non-native components....
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155766/ https://www.ncbi.nlm.nih.gov/pubmed/28165430 http://dx.doi.org/10.3390/molecules22020235 |