Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor

Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS) spectra, (1)H nuclear magnetic resonance (NM...

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Detalles Bibliográficos
Autores principales: Zayed, Mohamed F., Ihmaid, Saleh K., Ahmed, Hany E. A., El-Adl, Khaled, Asiri, Ahmed M., Omar, Abdelsattar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155771/
https://www.ncbi.nlm.nih.gov/pubmed/28125041
http://dx.doi.org/10.3390/molecules22020188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155771/
https://www.ncbi.nlm.nih.gov/pubmed/28125041
http://dx.doi.org/10.3390/molecules22020188

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