Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD

Silymarin is the most commonly used herbal medicine by patients with chronic liver disease. Silymarin flavonolignans undergo rapid first-pass metabolism primarily by glucuronidation. The aims of this investigation were: (1) to determine the association of UGT1A1*28 polymorphism with the area under t...

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Detalles Bibliográficos
Autores principales: Xie, Ying, Miranda, Sonia R., Hoskins, Janelle M., Hawke, Roy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155777/
https://www.ncbi.nlm.nih.gov/pubmed/28098838
http://dx.doi.org/10.3390/molecules22010142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155777/
https://www.ncbi.nlm.nih.gov/pubmed/28098838
http://dx.doi.org/10.3390/molecules22010142

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