Cargando…

Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD

Silymarin is the most commonly used herbal medicine by patients with chronic liver disease. Silymarin flavonolignans undergo rapid first-pass metabolism primarily by glucuronidation. The aims of this investigation were: (1) to determine the association of UGT1A1*28 polymorphism with the area under t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Ying, Miranda, Sonia R., Hoskins, Janelle M., Hawke, Roy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155777/ https://www.ncbi.nlm.nih.gov/pubmed/28098838 http://dx.doi.org/10.3390/molecules22010142

Ejemplares similares

Skin Protective Activity of Silymarin and its Flavonolignans
por: Vostálová, Jitka, et al.
Publicado: (2019)

Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota
por: Valentová, Kateřina, et al.
Publicado: (2020)

Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin
por: Vrba, Jiří, et al.
Publicado: (2020)

Effects of Dietary Components on Testosterone Metabolism via UDP-Glucuronosyltransferase
por: Jenkinson, Carl, et al.
Publicado: (2013)

Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview
por: Guillemette, Chantal, et al.
Publicado: (2004)

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication
por: Ouzzine, Mohamed, et al.
Publicado: (2014)

Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term
por: Reimers, Arne, et al.
Publicado: (2010)

Simple and Rapid HPLC Separation and Quantification of Flavonoid, Flavonolignans, and 2,3-Dehydroflavonolignans in Silymarin
por: Petrásková, Lucie, et al.
Publicado: (2020)

The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo
por: Pourová, Jana, et al.
Publicado: (2019)

Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs
por: Runge-Morris, Melissa, et al.
Publicado: (2009)

Structure and Protein–Protein Interactions of Human UDP-Glucuronosyltransferases
por: Fujiwara, Ryoichi, et al.
Publicado: (2016)

UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression
por: Grant, Delores J., et al.
Publicado: (2017)

Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues
por: Zhou, Lucas, et al.
Publicado: (2023)

Upregulation of UDP-Glucuronosyltransferases 1a1 and 1a7 Are Involved in Altered Puerarin Pharmacokinetics in Type II Diabetic Rats
por: Dong, Songtao, et al.
Publicado: (2018)

Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix Tablets for Enhanced Oral Bioavailability
por: Ahmad, Sher, et al.
Publicado: (2023)

The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase
por: Jiang, Li-Peng, et al.
Publicado: (2014)

Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases
por: Shan, Lina, et al.
Publicado: (2014)

Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression
por: Allain, Eric P., et al.
Publicado: (2020)

Dysregulated hepatic UDP-glucuronosyltransferases and flavonoids glucuronidation in experimental colitis
por: Zeng, Wanying, et al.
Publicado: (2022)

UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?
por: Stücker, I, et al.
Publicado: (2007)

Hepatic Metabolism of Sakuranetin and Its Modulating Effects on Cytochrome P450s and UDP-Glucuronosyltransferases
por: Jeong, Hyesoo, et al.
Publicado: (2018)

Multiple UDP-Glucuronosyltransferase and Sulfotransferase Enzymes are Responsible for the Metabolism of Verproside in Human Liver Preparations
por: Kim, Ju-Hyun, et al.
Publicado: (2017)

Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
por: Fretzayas, Andrew, et al.
Publicado: (2011)

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1
por: Cheng, Xuewei, et al.
Publicado: (2017)

Fluid intake, genetic variants of UDP-glucuronosyltransferases, and bladder cancer risk
por: Wang, J, et al.
Publicado: (2013)

Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics
por: Rouleau, Michèle, et al.
Publicado: (2017)

Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children
por: Neumann, Elizabeth, et al.
Publicado: (2016)

Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases
por: Pan, Yiou, et al.
Publicado: (2018)

Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice
por: Böhmdorfer, Michaela, et al.
Publicado: (2017)

Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs)
por: Zhang, Xu-Xin, et al.
Publicado: (2017)

Characterization of UDP-Glucuronosyltransferases and the Potential Contribution to Nicotine Tolerance in Myzus persicae
por: Pan, Yiou, et al.
Publicado: (2019)

Machine learning and structure-based modeling for the prediction of UDP-glucuronosyltransferase inhibition
por: Dudas, Balint, et al.
Publicado: (2022)

Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases
por: Illingworth, NA, et al.
Publicado: (2011)

Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia
por: Aoshima, Naoya, et al.
Publicado: (2014)

Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes
por: Kutsuno, Yuki, et al.
Publicado: (2013)

Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015
por: Darvishi Khezri, Hadi, et al.
Publicado: (2016)

Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer
por: Wang, Min, et al.
Publicado: (2013)

Anti-Cancer Drugs Elicit Re-Expression of UDP-Glucuronosyltransferases in Melanoma Cells
por: Dellinger, Ryan W., et al.
Publicado: (2012)

Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases
por: Greer, Aleksandra K., et al.
Publicado: (2014)

Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development
por: YABUSAKI, Risa, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hjcr9rnak39caf6dr1cscoslee