Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines

A highly diastereoselective cyclopropanation of cyclic enones with sulfur ylides was developed under catalyst-free conditions, producing multifunctional spirocyclopropanes in generally excellent yields (up to 99% yield and >99:1 d.r.). The asymmetric version of this method was realized by using a...

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Detalles Bibliográficos
Autores principales: Li, Yi, Li, Qing-Zhu, Huang, Li, Liang, Hong, Yang, Kai-Chuan, Leng, Hai-Jun, Liu, Yue, Shen, Xu-Dong, Gou, Xiao-Jun, Li, Jun-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155796/
https://www.ncbi.nlm.nih.gov/pubmed/28241452
http://dx.doi.org/10.3390/molecules22020328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155796/
https://www.ncbi.nlm.nih.gov/pubmed/28241452
http://dx.doi.org/10.3390/molecules22020328

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