Backstabbing P-gp: Side-Chain Cleaved Ecdysteroid 2,3-Dioxolanes Hyper-Sensitize MDR Cancer Cells to Doxorubicin without Efflux Inhibition

P-glycoprotein (P-gp, ABCB1) over-expression, causing a multi-drug resistant (MDR) phenotype, is a major problem in cancer chemotherapy that urgently requires novel approaches. Our previous studies showed certain ecdysteroid derivatives as promising chemo-sensitizers against MDR and non-MDR cancer c...

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Detalles Bibliográficos
Autores principales: Hunyadi, Attila, Csábi, József, Martins, Ana, Molnár, Joseph, Balázs, Attila, Tóth, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155823/
https://www.ncbi.nlm.nih.gov/pubmed/28125071
http://dx.doi.org/10.3390/molecules22020199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155823/
https://www.ncbi.nlm.nih.gov/pubmed/28125071
http://dx.doi.org/10.3390/molecules22020199

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