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Backstabbing P-gp: Side-Chain Cleaved Ecdysteroid 2,3-Dioxolanes Hyper-Sensitize MDR Cancer Cells to Doxorubicin without Efflux Inhibition

P-glycoprotein (P-gp, ABCB1) over-expression, causing a multi-drug resistant (MDR) phenotype, is a major problem in cancer chemotherapy that urgently requires novel approaches. Our previous studies showed certain ecdysteroid derivatives as promising chemo-sensitizers against MDR and non-MDR cancer c...

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Detalles Bibliográficos
Autores principales:	Hunyadi, Attila, Csábi, József, Martins, Ana, Molnár, Joseph, Balázs, Attila, Tóth, Gábor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155823/ https://www.ncbi.nlm.nih.gov/pubmed/28125071 http://dx.doi.org/10.3390/molecules22020199

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