Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment; however, the molecular basis underlying the plei...

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Detalles Bibliográficos
Autores principales: Donovan, Katherine A, An, Jian, Nowak, Radosław P, Yuan, Jingting C, Fink, Emma C, Berry, Bethany C, Ebert, Benjamin L, Fischer, Eric S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156078/
https://www.ncbi.nlm.nih.gov/pubmed/30067223
http://dx.doi.org/10.7554/eLife.38430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156078/
https://www.ncbi.nlm.nih.gov/pubmed/30067223
http://dx.doi.org/10.7554/eLife.38430

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