Cargando…

Chemistry and Hypoglycemic Activity of GPR119 Agonist ZB-16

This article is to highlight the chemical properties and primary pharmacology of novel GPR119 agonist ZB-16 and its analogs, which were rejected during the screening. Experiments were performed in vitro (specific activity, metabolism and cell toxicity) and in vivo (hypoglycemic activity and pharmaco...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tyurenkov, Ivan N., Kurkin, Denis V., Bakulin, Dmitry A., Volotova, Elena V., Morkovin, Evgeny I., Chafeev, Mikhail A., Karapetian, Ruben N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156125/ https://www.ncbi.nlm.nih.gov/pubmed/30283402 http://dx.doi.org/10.3389/fendo.2018.00543

Ejemplares similares

ZB-16, a Novel GPR119 Agonist, Relieves the Severity of Streptozotocin–Nicotinamide-Induced Diabetes in Rats
por: Tyurenkov, Ivan N., et al.
Publicado: (2017)

Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats
por: Kurkin, Denis V., et al.
Publicado: (2021)

Microbial biotransformation to obtain stilbene methylglucoside with GPR119 agonistic activity
por: Peng, Yu, et al.
Publicado: (2023)

β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation
por: Panaro, Brandon L., et al.
Publicado: (2017)

GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy
por: Im, Ji Hye, et al.
Publicado: (2018)

Correction: GPR119 agonist enhances gefitinib responsiveness through lactate-mediatedinhibition of autophagy
por: Im, Ji Hye, et al.
Publicado: (2022)

Oleoylethanolamide Exhibits GPR119-Dependent Inhibition of Osteoclast Function and GPR119-Independent Promotion of Osteoclast Apoptosis
por: Kim, Hyun-Ju, et al.
Publicado: (2020)

Synthesis, structure, and biological activity of 4-hetaryl-2-pyrrolidones containing a pyrazole ring
por: Gorodnicheva, Natal’ya V., et al.
Publicado: (2022)

Stimulating β-Cell Regeneration by Combining a GPR119 Agonist with a DPP-IV Inhibitor
por: Ansarullah,, et al.
Publicado: (2013)

GPR55 and GPR119 Receptors Contribute to the Processing of Neuropathic Pain in Rats
por: Zúñiga-Romero, Ángel, et al.
Publicado: (2022)

GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide
por: Im, Dong-Soon
Publicado: (2021)

In Vivo Efficacy of HD0471953: A Novel GPR119 Agonist for the Treatment of Type 2 Diabetes Mellitus
por: Kim, So Ra, et al.
Publicado: (2013)

Potential Metabolic and Behavioural Roles of the Putative Endo- cannabinoid Receptors GPR18, GPR55 and GPR119 in Feeding
por: Ramírez-Orozco, Ricardo E., et al.
Publicado: (2019)

Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice
por: McKillop, Aine M., et al.
Publicado: (2016)

Functional validation of ZbFAD2 and ZbFAD3 in the alkylamide biosynthesis pathway from Zanthoxylum bungeanum Maxim
por: Zhang, Jie, et al.
Publicado: (2022)

A custodial symmetry for $Zb\overline{\b}$
por: Agashe, K, et al.
Publicado: (2006)

OR24-01 Mutational Study of the GPR119 Receptor Binding Site
por: Rosales, Matthew D, et al.
Publicado: (2020)

Activation and signaling mechanism revealed by GPR119-G(s) complex structures
por: Qian, Yuxia, et al.
Publicado: (2022)

Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells
por: Ning, Y, et al.
Publicado: (2008)

The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo
por: Huan, Yi, et al.
Publicado: (2017)

Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-b][1,4]oxazine derivatives as potent GPR 119 agonists
por: Fang, Yuanying, et al.
Publicado: (2019)

DA-1241, a Novel GPR119 Agonist, Improves Hyperglycaemia by Inhibiting Hepatic Gluconeogenesis and Enhancing Insulin Secretion in Diabetic Mice
por: Kim, Youjin, et al.
Publicado: (2022)

Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119
por: Park, Eun-Young, et al.
Publicado: (2016)

$^{119}$Sn Mössbauer study of the implantation behaviour of $^{119}$In, $^{119}$Sn, $^{119m}$Sn, $^{119}$Sb and $^{119m}$Te ions in SiC
por: Petersen, J W, et al.
Publicado: (1985)

The Zb$\overline{b}$ vertex: implications for the Standard Model and beyond
por: Cornet, F, et al.
Publicado: (1994)

Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice
por: Higuchi, Sei, et al.
Publicado: (2020)

Peptide YY Is Critical for Acylethanolamine Receptor Gpr119-Induced Activation of Gastrointestinal Mucosal Responses
por: Cox, Helen M., et al.
Publicado: (2010)

Intestinal GPR119 activation by microbiota-derived metabolites impacts feeding behavior and energy metabolism
por: Igarashi, Miki, et al.
Publicado: (2022)

Gut Hormone Pharmacology of a Novel GPR119 Agonist (GSK1292263), Metformin, and Sitagliptin in Type 2 Diabetes Mellitus: Results from Two Randomized Studies
por: Nunez, Derek J., et al.
Publicado: (2014)

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells
por: Hodge, Daryl, et al.
Publicado: (2016)

Bidirectional GPR119 Agonism Requires Peptide YY and Glucose for Activity in Mouse and Human Colon Mucosa
por: Tough, Iain R, et al.
Publicado: (2018)

Formation of βTC3 and MIN6 Pseudoislets Changes the Expression Pattern of Gpr40, Gpr55, and Gpr119 Receptors and Improves Lysophosphatidylcholines-Potentiated Glucose-Stimulated Insulin Secretion
por: Drzazga, Anna, et al.
Publicado: (2020)

Efficacy and Safety of GPR119 Agonist DS-8500a in Japanese Patients with Type 2 Diabetes: a Randomized, Double-Blind, Placebo-Controlled, 12-Week Study
por: Yamada, Yuichiro, et al.
Publicado: (2018)

The decay of $]^{119}$Cd and $\^{119}$In isomers
por: Scheidemann, O, et al.
Publicado: (1976)

A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner
por: Miller, Sally, et al.
Publicado: (2017)

Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets
por: Ansarullah,, et al.
Publicado: (2016)

Targeting the GPR119/incretin axis: a promising new therapy for metabolic-associated fatty liver disease
por: Zhao, Jianan, et al.
Publicado: (2021)

Multiple tyrosine metabolites are GPR35 agonists
por: Deng, Huayun, et al.
Publicado: (2012)

Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides
por: Krasnov, Victor P., et al.
Publicado: (2023)

GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, But Not Female Mice
por: Ram, Akila, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_beo9d1nk5sfejl5lmsg0gr6i20