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Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease

Tracking bacterial evolution during chronic infection provides insights into how host selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen nontypeable Haemophilus influenzae (NTHi) infects the lower airways of patients suffering chronic obstructive pulmonary disea...

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Detalles Bibliográficos
Autores principales: Moleres, Javier, Fernández-Calvet, Ariadna, Ehrlich, Rachel L., Martí, Sara, Pérez-Regidor, Lucía, Euba, Begoña, Rodríguez-Arce, Irene, Balashov, Sergey, Cuevas, Ester, Liñares, Josefina, Ardanuy, Carmen, Martín-Santamaría, Sonsoles, Ehrlich, Garth D., Mell, Joshua Chang, Garmendia, Junkal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156194/
https://www.ncbi.nlm.nih.gov/pubmed/30254117
http://dx.doi.org/10.1128/mBio.01176-18