Persistent repair intermediates induce senescence

Double-stranded DNA breaks activate a DNA damage checkpoint in G2 phase to trigger a cell cycle arrest, which can be reversed to allow for recovery. However, damaged G2 cells can also permanently exit the cell cycle, going into senescence or apoptosis, raising the question how an individual cell dec...

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Detalles Bibliográficos
Autores principales: Feringa, F. M., Raaijmakers, J. A., Hadders, M. A., Vaarting, C., Macurek, L., Heitink, L., Krenning, L., Medema, R. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156224/
https://www.ncbi.nlm.nih.gov/pubmed/30254262
http://dx.doi.org/10.1038/s41467-018-06308-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156224/
https://www.ncbi.nlm.nih.gov/pubmed/30254262
http://dx.doi.org/10.1038/s41467-018-06308-9

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