Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons

Cell cycle reentry followed by neuronal hyperploidy and synaptic failure are two early hallmarks of Alzheimer’s disease (AD), however their functional connection remains unexplored. To address this question, we induced cell cycle reentry in cultured cortical neurons by expressing SV40 large T antige...

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Detalles Bibliográficos
Autores principales: Barrio-Alonso, E., Hernández-Vivanco, A., Walton, C. C., Perea, G., Frade, J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156334/
https://www.ncbi.nlm.nih.gov/pubmed/30254284
http://dx.doi.org/10.1038/s41598-018-32708-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156334/
https://www.ncbi.nlm.nih.gov/pubmed/30254284
http://dx.doi.org/10.1038/s41598-018-32708-4

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