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Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
Polycomb-group proteins are conserved chromatin factors that maintain the silencing of key developmental genes, notably the Hox gene clusters, outside of their expression domains. Depletion of Polycomb repressive complex 1 (PRC1) proteins typically results in chromatin unfolding, as well as ectopic...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156336/ https://www.ncbi.nlm.nih.gov/pubmed/30254245 http://dx.doi.org/10.1038/s41467-018-05945-4 |