Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition

Mitophagy eliminates dysfunctional mitochondria and thus plays a cardinal role in diabetic cardiomyopathy (DCM). We observed the favourable effects of melatonin on cardiomyocyte mitophagy in mice with DCM and elucidated their underlying mechanisms. Electron microscopy and flow cytometric analysis re...

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Detalles Bibliográficos
Autores principales: Wang, Shanjie, Zhao, Zhijing, Feng, Xinyu, Cheng, Zheng, Xiong, Zhenyu, Wang, Tingting, Lin, Jie, Zhang, Mingming, Hu, Jianqiang, Fan, Yanhong, Reiter, Russel J., Wang, Haichang, Sun, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156356/
https://www.ncbi.nlm.nih.gov/pubmed/30063115
http://dx.doi.org/10.1111/jcmm.13802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156356/
https://www.ncbi.nlm.nih.gov/pubmed/30063115
http://dx.doi.org/10.1111/jcmm.13802

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