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Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition
Mitophagy eliminates dysfunctional mitochondria and thus plays a cardinal role in diabetic cardiomyopathy (DCM). We observed the favourable effects of melatonin on cardiomyocyte mitophagy in mice with DCM and elucidated their underlying mechanisms. Electron microscopy and flow cytometric analysis re...
Autores principales: | Wang, Shanjie, Zhao, Zhijing, Feng, Xinyu, Cheng, Zheng, Xiong, Zhenyu, Wang, Tingting, Lin, Jie, Zhang, Mingming, Hu, Jianqiang, Fan, Yanhong, Reiter, Russel J., Wang, Haichang, Sun, Dongdong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156356/ https://www.ncbi.nlm.nih.gov/pubmed/30063115 http://dx.doi.org/10.1111/jcmm.13802 |
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