The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity

Dictamni Cortex (DC) has been reported to be associated with acute hepatitis in clinic and may lead to a selective sub-chronic hepatotoxicity in rats. Nevertheless, the potent toxic ingredient and the underlying mechanism remain unknown. Dictamnine (DTN), the main alkaloid from DC, possesses a furan...

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Detalles Bibliográficos
Autores principales: Li, Zhuo-Qing, Jiang, Li-Long, Zhao, Dong-Sheng, Zhou, Jing, Wang, Ling-Li, Wu, Zi-Tian, Zheng, Xian, Shi, Zi-Qi, Li, Ping, Li, Hui-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156363/
https://www.ncbi.nlm.nih.gov/pubmed/30283337
http://dx.doi.org/10.3389/fphar.2018.01033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156363/
https://www.ncbi.nlm.nih.gov/pubmed/30283337
http://dx.doi.org/10.3389/fphar.2018.01033

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