Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile

A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and delta (DOP) opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors. The majority of the new ligands dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Vinod, Polgar, Willma E., Cami-Kobeci, Gerta, Thomas, Mark P., Khroyan, Taline V., Toll, Lawrence, Husbands, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156383/
https://www.ncbi.nlm.nih.gov/pubmed/30283364
http://dx.doi.org/10.3389/fpsyt.2018.00430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156383/
https://www.ncbi.nlm.nih.gov/pubmed/30283364
http://dx.doi.org/10.3389/fpsyt.2018.00430

Ejemplares similares