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Estimating sources and sinks of malaria parasites in Madagascar

In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence dat...

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Autores principales: Ihantamalala, Felana Angella, Herbreteau, Vincent, Rakotoarimanana, Feno M. J., Rakotondramanga, Jean Marius, Cauchemez, Simon, Rahoilijaona, Bienvenue, Pennober, Gwenaëlle, Buckee, Caroline O., Rogier, Christophe, Metcalf, C. J. E., Wesolowski, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156502/
https://www.ncbi.nlm.nih.gov/pubmed/30254280
http://dx.doi.org/10.1038/s41467-018-06290-2
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author Ihantamalala, Felana Angella
Herbreteau, Vincent
Rakotoarimanana, Feno M. J.
Rakotondramanga, Jean Marius
Cauchemez, Simon
Rahoilijaona, Bienvenue
Pennober, Gwenaëlle
Buckee, Caroline O.
Rogier, Christophe
Metcalf, C. J. E.
Wesolowski, Amy
author_facet Ihantamalala, Felana Angella
Herbreteau, Vincent
Rakotoarimanana, Feno M. J.
Rakotondramanga, Jean Marius
Cauchemez, Simon
Rahoilijaona, Bienvenue
Pennober, Gwenaëlle
Buckee, Caroline O.
Rogier, Christophe
Metcalf, C. J. E.
Wesolowski, Amy
author_sort Ihantamalala, Felana Angella
collection PubMed
description In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify travel routes relevant to malaria transmission in Madagascar. We find that the primary hubs of parasite importation are in a spatially connected area of the central highlands. Surprisingly, sources of these imported infections are not spatially clustered. We then related these source locations directly to clinical cases in the low-transmission area of the capital. We find that in the capital, a major sink, the primary sources of infection are along the more populated coastal areas, although these sources are seasonally variable. Our results have implications for targeting interventions at source locations to achieve local or national malaria control goals.
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spelling pubmed-61565022018-09-27 Estimating sources and sinks of malaria parasites in Madagascar Ihantamalala, Felana Angella Herbreteau, Vincent Rakotoarimanana, Feno M. J. Rakotondramanga, Jean Marius Cauchemez, Simon Rahoilijaona, Bienvenue Pennober, Gwenaëlle Buckee, Caroline O. Rogier, Christophe Metcalf, C. J. E. Wesolowski, Amy Nat Commun Article In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify travel routes relevant to malaria transmission in Madagascar. We find that the primary hubs of parasite importation are in a spatially connected area of the central highlands. Surprisingly, sources of these imported infections are not spatially clustered. We then related these source locations directly to clinical cases in the low-transmission area of the capital. We find that in the capital, a major sink, the primary sources of infection are along the more populated coastal areas, although these sources are seasonally variable. Our results have implications for targeting interventions at source locations to achieve local or national malaria control goals. Nature Publishing Group UK 2018-09-25 /pmc/articles/PMC6156502/ /pubmed/30254280 http://dx.doi.org/10.1038/s41467-018-06290-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ihantamalala, Felana Angella
Herbreteau, Vincent
Rakotoarimanana, Feno M. J.
Rakotondramanga, Jean Marius
Cauchemez, Simon
Rahoilijaona, Bienvenue
Pennober, Gwenaëlle
Buckee, Caroline O.
Rogier, Christophe
Metcalf, C. J. E.
Wesolowski, Amy
Estimating sources and sinks of malaria parasites in Madagascar
title Estimating sources and sinks of malaria parasites in Madagascar
title_full Estimating sources and sinks of malaria parasites in Madagascar
title_fullStr Estimating sources and sinks of malaria parasites in Madagascar
title_full_unstemmed Estimating sources and sinks of malaria parasites in Madagascar
title_short Estimating sources and sinks of malaria parasites in Madagascar
title_sort estimating sources and sinks of malaria parasites in madagascar
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156502/
https://www.ncbi.nlm.nih.gov/pubmed/30254280
http://dx.doi.org/10.1038/s41467-018-06290-2
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