Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species

Gliomas are highly malignant brain tumours characterised by extensive areas of poor perfusion which subsequently leads to hypoxia and reduced survival. Therapies that address the hypoxic microenvironment are likely to significantly improve patient outcomes. Verteporfin, a benzoporphyrin-like drug, h...

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Detalles Bibliográficos
Autores principales: Eales, Katherine L., Wilkinson, Edward A., Cruickshank, Garth, Tucker, James H. R., Tennant, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156578/
https://www.ncbi.nlm.nih.gov/pubmed/30254296
http://dx.doi.org/10.1038/s41598-018-32727-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156578/
https://www.ncbi.nlm.nih.gov/pubmed/30254296
http://dx.doi.org/10.1038/s41598-018-32727-1

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