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Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species
Gliomas are highly malignant brain tumours characterised by extensive areas of poor perfusion which subsequently leads to hypoxia and reduced survival. Therapies that address the hypoxic microenvironment are likely to significantly improve patient outcomes. Verteporfin, a benzoporphyrin-like drug, h...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156578/ https://www.ncbi.nlm.nih.gov/pubmed/30254296 http://dx.doi.org/10.1038/s41598-018-32727-1 |