An OB-fold complex controls the repair pathways for DNA double-strand breaks

53BP1 with its downstream proteins, RIF1, PTIP and REV7, antagonizes BRCA1-dependent homologous recombination (HR) and promotes non-homologous end joining (NHEJ) in an unclear manner. Here we show that REV7 forms a complex with two proteins, FAM35A and C20ORF196. We demonstrate that FAM35A preferent...

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Detalles Bibliográficos
Autores principales: Gao, Shengxian, Feng, Sumin, Ning, Shaokai, Liu, Jingyan, Zhao, Huayu, Xu, Yixi, Shang, Jinfeng, Li, Kejiao, Li, Qing, Guo, Rong, Xu, Dongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156606/
https://www.ncbi.nlm.nih.gov/pubmed/30254264
http://dx.doi.org/10.1038/s41467-018-06407-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156606/
https://www.ncbi.nlm.nih.gov/pubmed/30254264
http://dx.doi.org/10.1038/s41467-018-06407-7

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