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An OB-fold complex controls the repair pathways for DNA double-strand breaks

53BP1 with its downstream proteins, RIF1, PTIP and REV7, antagonizes BRCA1-dependent homologous recombination (HR) and promotes non-homologous end joining (NHEJ) in an unclear manner. Here we show that REV7 forms a complex with two proteins, FAM35A and C20ORF196. We demonstrate that FAM35A preferent...

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Detalles Bibliográficos
Autores principales:	Gao, Shengxian, Feng, Sumin, Ning, Shaokai, Liu, Jingyan, Zhao, Huayu, Xu, Yixi, Shang, Jinfeng, Li, Kejiao, Li, Qing, Guo, Rong, Xu, Dongyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156606/ https://www.ncbi.nlm.nih.gov/pubmed/30254264 http://dx.doi.org/10.1038/s41467-018-06407-7

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