Ehrlichia type IV secretion system effector Etf-2 binds to active RAB5 and delays endosome maturation

Ehrlichia chaffeensis, an obligatory intracellular bacterium, infects monocytes/macrophages by sequestering a regulator of endosomal traffic, the small GTPase RAB5, on its membrane-bound inclusions to avoid routing to host-cell phagolysosomes. How RAB5 is sequestered on ehrlichial inclusions is poor...

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Detalles Bibliográficos
Autores principales: Yan, Qi, Lin, Mingqun, Huang, Weiyan, Teymournejad, Omid, Johnson, Jennifer M., Hays, Franklin A., Liang, Zhimin, Li, Guangpu, Rikihisa, Yasuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156607/
https://www.ncbi.nlm.nih.gov/pubmed/30181274
http://dx.doi.org/10.1073/pnas.1806904115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156607/
https://www.ncbi.nlm.nih.gov/pubmed/30181274
http://dx.doi.org/10.1073/pnas.1806904115

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